产品货号：
Z11440
中文名称：
ATM抗体
英文名称：
Anti-ATM Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ATM Antibody |
| 指标别名 | A T mutated;AT1;ATA;ataxia telangiectasia mutated;ATC;ATD;ATDC;ATE;ATM;Serine protein kinase ATM;TEL1;TELO1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | ATM |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human ATM(36-50aa DPETIKHLDRHSDSK),different from the related rat and mouse sequences by two amino acids. |
| 实际分子量 | 350KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ATM(ataxia telangiectasia mutated),also known as TEL1 or TELO1,is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks.The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control.Linkage analysis of ataxia-telangiectasia led to mapping of the ATM gene to chromosome 11q22.3.Using an antiserum developed to a peptide corresponding to the deduced amino acid sequence of ATM,the ATM protein is a single,high molecular weight protein predominantly confined to the nucleus of human fibroblasts,although it is present in both nuclear and microsomal fractions from human lymphoblast cells and peripheral blood lymphocytes.Overexpression of ATM cDNA in AT cells enhanced their survival after radiation exposure,decreased radiation-induced chromosome aberrations,reduced radioresistant DNA synthesis,and partially corrected defective cell cycle checkpoints and induction of stress-activated protein kinase.ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors,in a telomere-independent manner.ATM functions directly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly. |
| Uniprot ID | Q13315 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | ataxia telangiectasia mutated |
| 蛋白名全称 | Serine-protein kinase ATM |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：ATM抗体，ATM多抗，Anti-ATM Antibody